Assay Detail
Functional
CHEMBL3860177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.90 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551842 | LOBARIC ACID | — | 1 | 5.85 |
| CHEMBL171637 | PHYSODIC ACID | — | 1 | 4.49 |
| CHEMBL368810 | — | — | 1 | 4.36 |
| CHEMBL220486 | VARIOLARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551842 | LOBARIC ACID | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL171637 | PHYSODIC ACID | EC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL368810 | — | EC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL220486 | VARIOLARIC ACID | EC50 | > | 100000.0 | nM | - |