Assay Detail
Binding
CHEMBL3861265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human recombinant VPS34 (unknown origin) using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or high-throughput membrane capture assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Class II Phosphoinositide 3-Kinases as Novel Drug Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.86 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229535 | — | — | 1 | 6.50 |
| CHEMBL1241857 | — | — | 1 | 6.08 |
| CHEMBL3922359 | — | — | 1 | 5.00 |
| CHEMBL3913354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229535 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1241857 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3922359 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3913354 | — | IC50 | = | 2300000.0 | nM | - |