Assay Detail
Functional
CHEMBL3861288
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.82 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3952862 | — | — | 1 | 6.19 |
| CHEMBL3965777 | — | — | 1 | 5.99 |
| CHEMBL3925165 | — | — | 1 | 5.99 |
| CHEMBL3916152 | — | — | 1 | 5.96 |
| CHEMBL3974252 | — | — | 1 | 5.93 |
| CHEMBL3417314 | — | — | 1 | 5.92 |
| CHEMBL3944111 | — | — | 1 | 5.90 |
| CHEMBL3983212 | — | — | 1 | 5.89 |
| CHEMBL3892041 | — | — | 1 | 5.88 |
| CHEMBL3903308 | — | — | 1 | 5.87 |
| CHEMBL3417315 | — | — | 1 | 5.84 |
| CHEMBL3928971 | — | — | 1 | 5.84 |
| CHEMBL1172284 | — | — | 1 | 5.82 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 5.80 |
| CHEMBL3417313 | — | — | 1 | 5.75 |
| CHEMBL3943005 | — | — | 1 | 5.74 |
| CHEMBL3894339 | — | — | 1 | 5.74 |
| CHEMBL3961541 | — | — | 1 | 5.72 |
| CHEMBL3934044 | — | — | 1 | 5.69 |
| CHEMBL3980631 | — | — | 1 | 5.69 |
| CHEMBL3920061 | — | — | 1 | 5.69 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.67 |
| CHEMBL3954567 | — | — | 1 | 5.65 |
| CHEMBL3951763 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3952862 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3965777 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3925165 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3916152 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3974252 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL3417314 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3944111 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3983212 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3892041 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3903308 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3417315 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3928971 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL1172284 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3417313 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3943005 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL3894339 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL3961541 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL3934044 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL3980631 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL3920061 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL301982 | CELASTROL | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3954567 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL3951763 | — | IC50 | = | 2550.0 | nM | 5.59 |