Assay Detail
Binding
CHEMBL3861735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.41 | 4.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397270 | — | — | 1 | 4.48 |
| CHEMBL137953 | — | — | 1 | 4.33 |
| CHEMBL3980196 | — | — | 1 | - |
| CHEMBL440470 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397270 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL137953 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3980196 | — | IC50 | - | — | - | |
| CHEMBL440470 | — | IC50 | = | 149000.0 | nM | - |