Assay Detail
Functional
CHEMBL3861876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SNU16 cells incubated for 4 days by CCK8 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.82 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3681278 | — | — | 1 | 8.59 |
| CHEMBL3681314 | — | — | 1 | 8.22 |
| CHEMBL3891894 | — | — | 1 | 7.77 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | 2.0 | 1 | 7.77 |
| CHEMBL3895337 | — | — | 1 | 7.75 |
| CHEMBL3676329 | — | — | 1 | 7.28 |
| CHEMBL3959997 | — | — | 1 | 7.28 |
| CHEMBL3681287 | — | — | 1 | 7.11 |
| CHEMBL3681317 | — | — | 1 | 7.09 |
| CHEMBL3681244 | — | — | 1 | 7.08 |
| CHEMBL3941474 | — | — | 1 | 6.72 |
| CHEMBL3976548 | — | — | 1 | 6.44 |
| CHEMBL3934547 | — | — | 1 | 6.42 |
| CHEMBL3984621 | — | — | 1 | 6.26 |
| CHEMBL3956001 | — | — | 1 | 5.54 |
| CHEMBL3981956 | — | — | 1 | 5.48 |
| CHEMBL3947281 | — | — | 1 | 5.05 |
| CHEMBL3905685 | — | — | 1 | 4.82 |
| CHEMBL3952373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3681278 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3681314 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3891894 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3895337 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3676329 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3959997 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3681287 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3681317 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3681244 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3941474 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3976548 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3934547 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3984621 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3956001 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3981956 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3947281 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3905685 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3952373 | — | IC50 | - | — | - |