Assay Detail
Functional
CHEMBL3861877
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Antiproliferative activity against human HCT116 cells incubated for 4 days by CCK8 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.24 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3941474 | — | — | 1 | 6.33 |
| CHEMBL3681287 | — | — | 1 | 5.82 |
| CHEMBL3976548 | — | — | 1 | 5.58 |
| CHEMBL3956001 | — | — | 1 | 5.57 |
| CHEMBL3681314 | — | — | 1 | 5.50 |
| CHEMBL3984621 | — | — | 1 | 5.44 |
| CHEMBL3681244 | — | — | 1 | 5.42 |
| CHEMBL3681278 | — | — | 1 | 5.39 |
| CHEMBL3959997 | — | — | 1 | 5.28 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | 2.0 | 1 | 5.23 |
| CHEMBL3981956 | — | — | 1 | 5.09 |
| CHEMBL3891894 | — | — | 1 | 5.05 |
| CHEMBL3947281 | — | — | 1 | 5.03 |
| CHEMBL3895337 | — | — | 1 | 5.01 |
| CHEMBL3676329 | — | — | 1 | 4.96 |
| CHEMBL3934547 | — | — | 1 | 4.77 |
| CHEMBL3952373 | — | — | 1 | 4.48 |
| CHEMBL3681317 | — | — | 1 | 4.43 |
| CHEMBL3905685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3941474 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3681287 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3976548 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3956001 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3681314 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3984621 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3681244 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3681278 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3959997 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3981956 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3891894 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3947281 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3895337 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3676329 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3934547 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3952373 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3681317 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3905685 | — | IC50 | > | 20000.0 | nM | - |