Assay Detail
Functional
CHEMBL3862364
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lignans from the Australian Endemic Plant Austrobaileya scandens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.59 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.70 |
| CHEMBL483004 | — | — | 1 | 7.80 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 7.75 |
| CHEMBL3964168 | — | — | 1 | 7.33 |
| CHEMBL509850 | AUSTROBAILIGNAN 1 | — | 1 | 7.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.44 |
| CHEMBL3923679 | — | — | 1 | 6.08 |
| CHEMBL3923830 | — | — | 1 | 5.79 |
| CHEMBL3978563 | — | — | 1 | 5.72 |
| CHEMBL3951391 | — | — | 1 | 5.69 |
| CHEMBL3896728 | — | — | 1 | 5.29 |
| CHEMBL3322944 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL483004 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3964168 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL509850 | AUSTROBAILIGNAN 1 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3923679 | — | IC50 | = | 823.0 | nM | 6.08 |
| CHEMBL3923830 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL3978563 | — | IC50 | = | 1907.0 | nM | 5.72 |
| CHEMBL3951391 | — | IC50 | = | 2062.0 | nM | 5.69 |
| CHEMBL3896728 | — | IC50 | = | 5109.0 | nM | 5.29 |
| CHEMBL3322944 | — | IC50 | = | 6363.0 | nM | 5.20 |