Assay Detail

CHEMBL3862716

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Functional

Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCT-116
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata.

Gunasekera SP, Imperial L, Garst C, Ratnayake R, Dang LH, Paul VJ, Luesch H.
J Nat Prod (2016) 79 : 1867 -1871
PubMed 27380142 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.76	9.32

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39541	DOLASTATIN-10	2.0	1	9.32
CHEMBL1173445	LARGAZOLE	—	1	8.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39541	DOLASTATIN-10	IC50	=	0.48	nM	9.32
CHEMBL1173445	LARGAZOLE	IC50	=	6.41	nM	8.19