Assay Detail
Binding
CHEMBL3862725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aurora kinase B/Inner centromere protein (CHEMBL3430907) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.26 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 8.96 |
| CHEMBL3600873 | MK-5108 | 1.0 | 1 | 8.83 |
| CHEMBL3921246 | — | — | 1 | 6.82 |
| CHEMBL3903187 | — | — | 1 | 6.08 |
| CHEMBL3985313 | — | — | 1 | 5.85 |
| CHEMBL3904239 | — | — | 1 | 5.81 |
| CHEMBL3915550 | — | — | 1 | 5.77 |
| CHEMBL3975102 | — | — | 1 | 5.58 |
| CHEMBL3932394 | — | — | 1 | 5.57 |
| CHEMBL3924918 | — | — | 1 | 5.00 |
| CHEMBL3941377 | — | — | 1 | 4.64 |
| CHEMBL3983087 | — | — | 1 | - |
| CHEMBL3913242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3600873 | MK-5108 | IC50 | = | 1.49 | nM | 8.83 |
| CHEMBL3921246 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3903187 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3985313 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3904239 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3915550 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3975102 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3932394 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3924918 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3941377 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3983087 | — | IC50 | - | — | - | |
| CHEMBL3913242 | — | IC50 | - | — | - |