Assay Detail
Functional
CHEMBL3863846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-361/DYT2 cells assessed as decrease in cell viability after 4 days by MTS assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-361 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.70 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3892545 | — | — | 1 | 10.15 |
| CHEMBL3911475 | — | — | 1 | 9.89 |
| CHEMBL3893211 | — | — | 1 | 9.66 |
| CHEMBL3892053 | — | — | 1 | 9.57 |
| CHEMBL3958257 | — | — | 1 | 9.57 |
| CHEMBL3974123 | — | — | 1 | 9.51 |
| CHEMBL3920542 | — | — | 1 | 9.35 |
| CHEMBL3911603 | — | — | 1 | 9.17 |
| CHEMBL3973142 | — | — | 1 | 9.08 |
| CHEMBL3929440 | — | — | 1 | 9.05 |
| CHEMBL3974558 | — | — | 1 | 9.02 |
| CHEMBL3981225 | — | — | 1 | 8.97 |
| CHEMBL3973223 | — | — | 1 | 8.78 |
| CHEMBL3938483 | — | — | 1 | 8.71 |
| CHEMBL3911210 | — | — | 1 | 8.47 |
| CHEMBL3928982 | — | — | 1 | 8.31 |
| CHEMBL3902102 | — | — | 1 | 8.21 |
| CHEMBL3965726 | — | — | 1 | 8.20 |
| CHEMBL3981142 | — | — | 1 | 8.19 |
| CHEMBL3944667 | — | — | 1 | 8.19 |
| CHEMBL3965381 | — | — | 1 | 8.04 |
| CHEMBL3920070 | — | — | 1 | 7.78 |
| CHEMBL3910548 | — | — | 1 | 7.66 |
| CHEMBL3902188 | — | — | 1 | 7.62 |
| CHEMBL3981602 | — | — | 1 | 7.57 |
| CHEMBL3945137 | — | — | 1 | 7.48 |
| CHEMBL3901492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3892545 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL3911475 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3893211 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL3892053 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3958257 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3974123 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3920542 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL3911603 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL3973142 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL3929440 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3974558 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL3981225 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL3973223 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL3938483 | — | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL3911210 | — | IC50 | = | 3.37 | nM | 8.47 |
| CHEMBL3928982 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3902102 | — | IC50 | = | 6.09 | nM | 8.21 |
| CHEMBL3965726 | — | IC50 | = | 6.32 | nM | 8.20 |
| CHEMBL3981142 | — | IC50 | = | 6.45 | nM | 8.19 |
| CHEMBL3944667 | — | IC50 | = | 6.39 | nM | 8.19 |
| CHEMBL3965381 | — | IC50 | = | 9.05 | nM | 8.04 |
| CHEMBL3920070 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL3910548 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3902188 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3981602 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL3945137 | — | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL3901492 | — | IC50 | > | 1000.0 | nM | - |