Assay Detail
Functional
CHEMBL3863848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KB 8.5 cells expressing MDR1 assessed as decrease in cell viability after 4 days by MTS assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.68 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3893211 | — | — | 1 | 9.15 |
| CHEMBL3892545 | — | — | 1 | 8.99 |
| CHEMBL3911475 | — | — | 1 | 8.96 |
| CHEMBL3929440 | — | — | 1 | 8.56 |
| CHEMBL3938483 | — | — | 1 | 8.34 |
| CHEMBL3974123 | — | — | 1 | 8.26 |
| CHEMBL3920542 | — | — | 1 | 8.26 |
| CHEMBL3911603 | — | — | 1 | 8.10 |
| CHEMBL3958257 | — | — | 1 | 7.87 |
| CHEMBL3974558 | — | — | 1 | 7.87 |
| CHEMBL3973142 | — | — | 1 | 7.81 |
| CHEMBL3981142 | — | — | 1 | 7.76 |
| CHEMBL3965726 | — | — | 1 | 7.70 |
| CHEMBL3902102 | — | — | 1 | 7.55 |
| CHEMBL3892053 | — | — | 1 | 7.50 |
| CHEMBL3981225 | — | — | 1 | 7.47 |
| CHEMBL3944667 | — | — | 1 | 7.41 |
| CHEMBL3965381 | — | — | 1 | 7.33 |
| CHEMBL3911210 | — | — | 1 | 7.27 |
| CHEMBL3920070 | — | — | 1 | 7.16 |
| CHEMBL3928982 | — | — | 1 | 7.03 |
| CHEMBL3910548 | — | — | 1 | 6.98 |
| CHEMBL3973223 | — | — | 1 | 6.85 |
| CHEMBL3902188 | — | — | 1 | 6.75 |
| CHEMBL3945137 | — | — | 1 | 6.70 |
| CHEMBL3981602 | — | — | 1 | 6.10 |
| CHEMBL3901492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3893211 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3892545 | — | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL3911475 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3929440 | — | IC50 | = | 2.77 | nM | 8.56 |
| CHEMBL3938483 | — | IC50 | = | 4.53 | nM | 8.34 |
| CHEMBL3974123 | — | IC50 | = | 5.47 | nM | 8.26 |
| CHEMBL3920542 | — | IC50 | = | 5.52 | nM | 8.26 |
| CHEMBL3911603 | — | IC50 | = | 7.88 | nM | 8.10 |
| CHEMBL3958257 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL3974558 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL3973142 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL3981142 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL3965726 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL3902102 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL3892053 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL3981225 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL3944667 | — | IC50 | = | 39.4 | nM | 7.41 |
| CHEMBL3965381 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL3911210 | — | IC50 | = | 53.9 | nM | 7.27 |
| CHEMBL3920070 | — | IC50 | = | 69.2 | nM | 7.16 |
| CHEMBL3928982 | — | IC50 | = | 93.7 | nM | 7.03 |
| CHEMBL3910548 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3973223 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3902188 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3945137 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL3981602 | — | IC50 | = | 788.0 | nM | 6.10 |
| CHEMBL3901492 | — | IC50 | > | 1000.0 | nM | - |