Assay Detail
Binding
CHEMBL3863985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.40 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3918282 | — | — | 1 | 8.60 |
| CHEMBL3979590 | — | — | 1 | 8.60 |
| CHEMBL3941865 | — | — | 1 | 8.54 |
| CHEMBL3894678 | — | — | 1 | 8.50 |
| CHEMBL3890247 | — | — | 1 | 8.46 |
| CHEMBL3952924 | — | — | 1 | 8.45 |
| CHEMBL3965237 | — | — | 1 | 8.35 |
| CHEMBL3907263 | — | — | 1 | 8.30 |
| CHEMBL3909363 | — | — | 1 | 8.17 |
| CHEMBL3935199 | — | — | 1 | 8.13 |
| CHEMBL3971463 | — | — | 1 | 8.12 |
| CHEMBL3923939 | — | — | 1 | 8.02 |
| CHEMBL11493 | — | — | 1 | 7.98 |
| CHEMBL3916231 | — | — | 1 | 7.78 |
| CHEMBL3931813 | — | — | 1 | 7.71 |
| CHEMBL3959292 | — | — | 1 | 7.58 |
| CHEMBL3904892 | — | — | 1 | 7.57 |
| CHEMBL3927228 | — | — | 1 | 7.54 |
| CHEMBL3889802 | — | — | 1 | 7.48 |
| CHEMBL3890835 | — | — | 1 | 7.42 |
| CHEMBL3895932 | — | — | 1 | 7.41 |
| CHEMBL3899193 | — | — | 1 | 7.33 |
| CHEMBL3944169 | — | — | 1 | 7.30 |
| CHEMBL3957984 | — | — | 1 | 7.27 |
| CHEMBL3944646 | — | — | 1 | 7.25 |
| CHEMBL3979186 | — | — | 1 | 7.23 |
| CHEMBL3970990 | — | — | 1 | 7.13 |
| CHEMBL3126735 | — | — | 1 | 6.94 |
| CHEMBL3950591 | — | — | 1 | 6.84 |
| CHEMBL3908243 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3918282 | — | Ki | = | 2.53 | nM | 8.60 |
| CHEMBL3979590 | — | Ki | = | 2.54 | nM | 8.60 |
| CHEMBL3941865 | — | Ki | = | 2.92 | nM | 8.54 |
| CHEMBL3894678 | — | Ki | = | 3.17 | nM | 8.50 |
| CHEMBL3890247 | — | Ki | = | 3.43 | nM | 8.46 |
| CHEMBL3952924 | — | Ki | = | 3.58 | nM | 8.45 |
| CHEMBL3965237 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL3907263 | — | Ki | = | 4.98 | nM | 8.30 |
| CHEMBL3909363 | — | Ki | = | 6.72 | nM | 8.17 |
| CHEMBL3935199 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL3971463 | — | Ki | = | 7.62 | nM | 8.12 |
| CHEMBL3923939 | — | Ki | = | 9.67 | nM | 8.02 |
| CHEMBL11493 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL3916231 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL3931813 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL3959292 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL3904892 | — | Ki | = | 27.2 | nM | 7.57 |
| CHEMBL3927228 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL3889802 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3890835 | — | Ki | = | 37.6 | nM | 7.42 |
| CHEMBL3895932 | — | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL3899193 | — | Ki | = | 47.2 | nM | 7.33 |
| CHEMBL3944169 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL3957984 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL3944646 | — | Ki | = | 56.3 | nM | 7.25 |
| CHEMBL3979186 | — | Ki | = | 58.7 | nM | 7.23 |
| CHEMBL3970990 | — | Ki | = | 74.3 | nM | 7.13 |
| CHEMBL3126735 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL3950591 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL3908243 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL3936184 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL3899819 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL3931765 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL3900352 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL3913879 | — | Ki | = | 636.0 | nM | 6.20 |
| CHEMBL3925079 | — | Ki | = | 752.0 | nM | 6.12 |
| CHEMBL3961296 | — | Ki | = | 915.0 | nM | 6.04 |
| CHEMBL3916742 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL1201192 | ARMODAFINIL | Ki | = | 3050.0 | nM | 5.52 |
| CHEMBL8946 | ETICLOPRIDE | Ki | - | — | - |