Assay Detail
Binding
CHEMBL3863993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma1 receptor in whole-guinea pig brain minus cerebellum homogenates incubated for 120 mins by radioligand binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.26 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11493 | — | — | 1 | 8.62 |
| CHEMBL3916231 | — | — | 1 | 8.39 |
| CHEMBL3126735 | — | — | 1 | 6.80 |
| CHEMBL3918282 | — | — | 1 | 6.47 |
| CHEMBL3931765 | — | — | 1 | 6.00 |
| CHEMBL1201192 | ARMODAFINIL | 4.0 | 1 | - |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11493 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3916231 | — | Ki | = | 4.03 | nM | 8.39 |
| CHEMBL3126735 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL3918282 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL3931765 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL1201192 | ARMODAFINIL | Ki | > | 100000.0 | nM | - |
| CHEMBL8946 | ETICLOPRIDE | Ki | - | — | - |