Assay Detail
Binding
CHEMBL3864020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at AR T877A mutant (unknown origin) transfected in human PC3 cells assessed as inhibition of DHT-induced receptor transcriptional activation after 24 hrs by PSA-luciferase reporter gene assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Triptophenolide from Tripterygium wilfordii as a Pan-antagonist of Androgen Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 6.41 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3039217 | TRIPTOPHENOLIDE | — | 2 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3039217 | TRIPTOPHENOLIDE | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL3039217 | TRIPTOPHENOLIDE | Inhibition | - | % | - |