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Assay Detail

CHEMBL3864069

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Functional
Antiviral activity against HRV1A infected in human HeLa cells assessed as reduction in virus-induced cytopathic effect incubated for 3 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus 1A
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Publication

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Mejdrová I, Chalupská D, Plačková P, Müller C, Šála M, Klíma M, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Strunin D, Weber J, Lee G, Matoušová M, Mertlíková-Kaiserová H, Ziebuhr J, Birkus G, Boura E, Nencka R.
J Med Chem (2017) 60 : 100 -118
PubMed 28004945 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.28 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3959713 1 7.21
CHEMBL3947384 1 7.16
CHEMBL3976651 1 7.12
CHEMBL3923414 1 6.18
CHEMBL3930509 1 6.14
CHEMBL3893537 1 6.00
CHEMBL3902513 1 5.27
CHEMBL3911522 1 5.17
CHEMBL3894217 1 -
CHEMBL3957128 1 -
CHEMBL3929556 1 -
CHEMBL3948449 1 -
CHEMBL3920652 1 -
CHEMBL3939697 1 -
CHEMBL3958915 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3959713 EC50 = 62.0 nM 7.21
CHEMBL3947384 EC50 = 69.0 nM 7.16
CHEMBL3976651 EC50 = 75.0 nM 7.12
CHEMBL3923414 EC50 = 655.0 nM 6.18
CHEMBL3930509 EC50 = 716.0 nM 6.14
CHEMBL3893537 EC50 = 990.0 nM 6.00
CHEMBL3902513 EC50 = 5421.0 nM 5.27
CHEMBL3911522 EC50 = 6756.0 nM 5.17
CHEMBL3894217 EC50 < 10.0 nM -
CHEMBL3957128 EC50 < 10.0 nM -
CHEMBL3929556 EC50 < 10.0 nM -
CHEMBL3948449 EC50 < 10.0 nM -
CHEMBL3920652 EC50 < 10.0 nM -
CHEMBL3939697 EC50 < 10.0 nM -
CHEMBL3958915 EC50 < 10.0 nM -