Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3864356

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Mip PPIase activity in Legionella pneumophila
ChEMBL ↗
54
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Legionella pneumophila
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Outer membrane protein MIP (CHEMBL1667669) ↗
Type SINGLE PROTEIN
Organism Legionella pneumophila

Publication

Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei.
Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville IH, Sarkar-Tyson M, Marshall LE, Schweimer K, Bruhn H, Rösch P, Harmer NJ, Sotriffer CA, Holzgrabe U.
Bioorg Med Chem (2016) 24 : 5134 -5147
PubMed 27591009 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 4.99 5.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3890138 — — 2 5.66
CHEMBL3949202 — — 2 5.62
CHEMBL3930292 — — 2 5.59
CHEMBL3950488 — — 2 5.50
CHEMBL3899080 — — 2 5.46
CHEMBL3941933 — — 2 5.41
CHEMBL3970282 — — 2 5.25
CHEMBL3924013 — — 2 5.24
CHEMBL3939283 — — 2 5.24
CHEMBL3970581 — — 2 5.12
CHEMBL3921322 — — 2 5.11
CHEMBL3911322 — — 2 5.10
CHEMBL3893328 — — 2 5.07
CHEMBL3922939 — — 2 5.06
CHEMBL3896009 — — 2 4.97
CHEMBL3902318 — — 2 4.94
CHEMBL3920840 — — 2 4.94
CHEMBL3936855 — — 2 4.89
CHEMBL3963890 — — 2 4.67
CHEMBL3959376 — — 2 4.38
CHEMBL3956723 — — 2 4.35
CHEMBL3955039 — — 2 4.10
CHEMBL3938828 — — 2 4.05
CHEMBL3914698 — — 2 4.03
CHEMBL3929171 — — 2 -
CHEMBL3931883 — — 2 -
CHEMBL3986405 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3890138 — IC50 = 2200.0 nM 5.66
CHEMBL3890138 — IC50 = 2238.72 nM 5.65
CHEMBL3949202 — IC50 = 2398.83 nM 5.62
CHEMBL3949202 — IC50 = 2400.0 nM 5.62
CHEMBL3930292 — IC50 = 2570.4 nM 5.59
CHEMBL3930292 — IC50 = 2600.0 nM 5.58
CHEMBL3950488 — IC50 = 3200.0 nM 5.50
CHEMBL3950488 — IC50 = 3235.94 nM 5.49
CHEMBL3899080 — IC50 = 3500.0 nM 5.46
CHEMBL3899080 — IC50 = 3467.37 nM 5.46
CHEMBL3941933 — IC50 = 3900.0 nM 5.41
CHEMBL3941933 — IC50 = 3890.45 nM 5.41
CHEMBL3970282 — IC50 = 5600.0 nM 5.25
CHEMBL3970282 — IC50 = 5623.41 nM 5.25
CHEMBL3939283 — IC50 = 5754.4 nM 5.24
CHEMBL3924013 — IC50 = 5800.0 nM 5.24
CHEMBL3939283 — IC50 = 5700.0 nM 5.24
CHEMBL3924013 — IC50 = 5754.4 nM 5.24
CHEMBL3970581 — IC50 = 7500.0 nM 5.12
CHEMBL3970581 — IC50 = 7585.78 nM 5.12
CHEMBL3921322 — IC50 = 7762.47 nM 5.11
CHEMBL3921322 — IC50 = 7700.0 nM 5.11
CHEMBL3911322 — IC50 = 7900.0 nM 5.10
CHEMBL3911322 — IC50 = 7943.28 nM 5.10
CHEMBL3893328 — IC50 = 8511.38 nM 5.07
CHEMBL3893328 — IC50 = 8600.0 nM 5.07
CHEMBL3922939 — IC50 = 8709.64 nM 5.06
CHEMBL3922939 — IC50 = 8700.0 nM 5.06
CHEMBL3896009 — IC50 = 10715.19 nM 4.97
CHEMBL3896009 — IC50 = 10700.0 nM 4.97
CHEMBL3920840 — IC50 = 11500.0 nM 4.94
CHEMBL3902318 — IC50 = 11400.0 nM 4.94
CHEMBL3902318 — IC50 = 11481.54 nM 4.94
CHEMBL3920840 — IC50 = 11481.54 nM 4.94
CHEMBL3936855 — IC50 = 12882.5 nM 4.89
CHEMBL3936855 — IC50 = 12800.0 nM 4.89
CHEMBL3963890 — IC50 = 21400.0 nM 4.67
CHEMBL3963890 — IC50 = 21379.62 nM 4.67
CHEMBL3959376 — IC50 = 41686.94 nM 4.38
CHEMBL3959376 — IC50 = 41500.0 nM 4.38
CHEMBL3956723 — IC50 = 44668.36 nM 4.35
CHEMBL3956723 — IC50 = 44500.0 nM 4.35
CHEMBL3955039 — IC50 = 79432.82 nM 4.10
CHEMBL3955039 — IC50 = 79200.0 nM 4.10
CHEMBL3938828 — IC50 = 89125.09 nM 4.05
CHEMBL3938828 — IC50 = 89300.0 nM 4.05
CHEMBL3914698 — IC50 = 94000.0 nM 4.03
CHEMBL3914698 — IC50 = 93325.43 nM 4.03
CHEMBL3986405 — IC50 > 100000.0 nM -
CHEMBL3986405 — IC50 > 100000.0 nM -