Assay Detail
Binding
CHEMBL3864398
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Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
CREB-binding protein/Histone acetyltransferase p300 (CHEMBL3883300) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.88 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3968533 | — | — | 1 | 6.04 |
| CHEMBL3897393 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3968533 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3897393 | — | EC50 | = | 1900.0 | nM | 5.72 |