Assay Detail
Binding
CHEMBL3864781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DNA-PK/Ku70/Ku85 using EPPLSQEAFADLWKK as substrate by HTRF assay relative to control
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.67 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795743 | — | — | 1 | 5.00 |
| CHEMBL3915703 | — | — | 1 | 4.92 |
| CHEMBL175883 | — | — | 1 | 4.90 |
| CHEMBL1795742 | — | — | 1 | 4.41 |
| CHEMBL3945937 | — | — | 1 | 4.11 |
| CHEMBL3950259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795743 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3915703 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL175883 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1795742 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL3945937 | — | IC50 | = | 78100.0 | nM | 4.11 |
| CHEMBL3950259 | — | IC50 | > | 100000.0 | nM | - |