Assay Detail
Binding
CHEMBL3865002
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Inhibition of Hepatitis C virus genotype 1b Con1 replicon NS5A transfected in human HuH7 cells assessed as decrease in replication of viral replicon after 4 days by luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate Con1) |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 10.23 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3919651 | — | — | 1 | 11.00 |
| CHEMBL3892720 | — | — | 1 | 11.00 |
| CHEMBL3891600 | — | — | 1 | 10.89 |
| CHEMBL3944264 | — | — | 1 | 10.89 |
| CHEMBL3960757 | — | — | 1 | 10.85 |
| CHEMBL3979298 | — | — | 1 | 10.85 |
| CHEMBL3899984 | — | — | 1 | 10.80 |
| CHEMBL3121846 | — | — | 1 | 10.66 |
| CHEMBL3980231 | — | — | 1 | 10.51 |
| CHEMBL3953012 | — | — | 1 | 10.03 |
| CHEMBL3889915 | — | — | 1 | 10.02 |
| CHEMBL3962172 | — | — | 1 | 9.97 |
| CHEMBL3917933 | — | — | 1 | 9.71 |
| CHEMBL3960050 | — | — | 1 | 9.55 |
| CHEMBL3898584 | — | — | 1 | 8.81 |
| CHEMBL3899945 | — | — | 1 | 8.13 |
| CHEMBL3915742 | — | — | 1 | - |
| CHEMBL3985488 | — | — | 1 | - |
| CHEMBL3977398 | — | — | 1 | - |
| CHEMBL3961720 | — | — | 1 | - |
| CHEMBL3973743 | — | — | 1 | - |
| CHEMBL3981757 | — | — | 1 | - |
| CHEMBL3965250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3919651 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3892720 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3891600 | — | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL3944264 | — | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL3960757 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL3979298 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL3899984 | — | EC50 | = | 0.016 | nM | 10.80 |
| CHEMBL3121846 | — | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL3980231 | — | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL3953012 | — | EC50 | = | 0.093 | nM | 10.03 |
| CHEMBL3889915 | — | EC50 | = | 0.095 | nM | 10.02 |
| CHEMBL3962172 | — | EC50 | = | 0.107 | nM | 9.97 |
| CHEMBL3917933 | — | EC50 | = | 0.193 | nM | 9.71 |
| CHEMBL3960050 | — | EC50 | = | 0.283 | nM | 9.55 |
| CHEMBL3898584 | — | EC50 | = | 1.54 | nM | 8.81 |
| CHEMBL3899945 | — | EC50 | = | 7.44 | nM | 8.13 |
| CHEMBL3915742 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL3985488 | — | EC50 | = | 0.007 | nM | - |
| CHEMBL3977398 | — | EC50 | = | 0.007 | nM | - |
| CHEMBL3961720 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL3973743 | — | EC50 | < | 0.03 | nM | - |
| CHEMBL3981757 | — | EC50 | < | 0.03 | nM | - |
| CHEMBL3965250 | — | EC50 | = | 0.008 | nM | - |