Assay Detail
Binding
CHEMBL3865025
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hepatitis C virus genotype 1a H77 replicon NS5A M28T mutant transfected in human HuH7 cells assessed as decrease in replication of viral replicon after 4 days by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate H77) |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 11.00 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3915742 | — | — | 1 | 11.00 |
| CHEMBL3960757 | — | — | 1 | - |
| CHEMBL3985488 | — | — | 1 | - |
| CHEMBL3977398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3915742 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3960757 | — | EC50 | = | 0.008 | nM | - |
| CHEMBL3985488 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL3977398 | — | EC50 | = | 0.007 | nM | - |