Assay Detail
Binding
CHEMBL3865059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Plasmodium falciparum PKG assessed as decrease in depletion of ATP by Kinase glo luciferase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent protein kinase (CHEMBL2169724) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.63 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3109011 | — | — | 1 | 5.65 |
| CHEMBL3770802 | — | — | 1 | 5.63 |
| CHEMBL3108913 | — | — | 1 | 5.62 |
| CHEMBL3108997 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3109011 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3770802 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL3108913 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL3108997 | — | IC50 | = | 2520.0 | nM | 5.60 |