Assay Detail
Binding
CHEMBL3865062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase substrate by horseradish peroxidase/choline oxidase-coupled assay
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent inhibitors of the lysophospholipase autotaxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.95 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3917975 | CAMBRITAXESTAT | 2.0 | 1 | 9.00 |
| CHEMBL3917466 | — | — | 1 | 8.70 |
| CHEMBL3946146 | — | — | 1 | 8.70 |
| CHEMBL3889955 | — | — | 1 | 8.70 |
| CHEMBL3186509 | — | — | 1 | 8.52 |
| CHEMBL3912114 | — | — | 1 | 8.52 |
| CHEMBL3944813 | — | — | 1 | 8.52 |
| CHEMBL3926932 | — | — | 1 | 8.30 |
| CHEMBL3983022 | — | — | 1 | 8.30 |
| CHEMBL3916898 | — | — | 1 | 8.22 |
| CHEMBL3982059 | — | — | 1 | 8.10 |
| CHEMBL3907343 | — | — | 1 | 8.00 |
| CHEMBL3964183 | — | — | 2 | 8.00 |
| CHEMBL3907905 | — | — | 1 | 7.77 |
| CHEMBL3953575 | — | — | 1 | 7.54 |
| CHEMBL3954360 | — | — | 1 | 7.41 |
| CHEMBL3934551 | — | — | 1 | 7.28 |
| CHEMBL3916907 | — | — | 1 | 7.17 |
| CHEMBL3945659 | — | — | 1 | 7.10 |
| CHEMBL3971187 | — | — | 1 | 6.49 |
| CHEMBL3899987 | — | — | 1 | 6.44 |
| CHEMBL3965701 | — | — | 1 | 6.35 |
| CHEMBL1889181 | — | — | 1 | 6.33 |
| CHEMBL1316911 | — | — | 1 | 6.20 |
| CHEMBL3928269 | — | — | 1 | 6.07 |
| CHEMBL3971151 | — | — | 1 | 6.02 |
| CHEMBL3935870 | — | — | 1 | 5.97 |
| CHEMBL3900026 | — | — | 1 | 5.91 |
| CHEMBL3925941 | — | — | 1 | 5.90 |
| CHEMBL3964218 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3917975 | CAMBRITAXESTAT | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3917466 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3889955 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3946146 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3186509 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3912114 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3944813 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3926932 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3983022 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3916898 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3982059 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3907343 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3964183 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3907905 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3953575 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3954360 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3934551 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3916907 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3945659 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3964183 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3971187 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL3899987 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL3965701 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL1889181 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL1316911 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL3928269 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL3971151 | — | IC50 | = | 957.0 | nM | 6.02 |
| CHEMBL3935870 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3900026 | — | IC50 | = | 1242.0 | nM | 5.91 |
| CHEMBL3925941 | — | IC50 | = | 1252.0 | nM | 5.90 |
| CHEMBL3964218 | — | IC50 | = | 1251.0 | nM | 5.90 |
| CHEMBL3982176 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3936895 | — | IC50 | = | 2631.0 | nM | 5.58 |
| CHEMBL3963088 | — | IC50 | = | 2884.0 | nM | 5.54 |
| CHEMBL3974169 | — | IC50 | = | 2974.0 | nM | 5.53 |
| CHEMBL3918210 | — | IC50 | = | 3436.0 | nM | 5.46 |
| CHEMBL3960120 | — | IC50 | = | 6774.0 | nM | 5.17 |
| CHEMBL1885417 | — | IC50 | = | 8811.0 | nM | 5.05 |
| CHEMBL3921184 | — | IC50 | = | 10980.0 | nM | 4.96 |