Assay Detail

CHEMBL3865099

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Binding

Inhibition of ATX in human plasma assessed as decrease in LPA C18:1 levels after 24 hrs by horseradish peroxidase/choline oxidase-coupled assay

ChEMBL ↗

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Target

Autotaxin (CHEMBL3691) ↗

Open DB target context

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Autotaxin (CHEMBL3691) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Autotaxin

CHEMBL3691

Anchored from Assay target.

Protein identity Autotaxin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Tissue	Plasma
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Autotaxin (CHEMBL3691) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of potent inhibitors of the lysophospholipase autotaxin.

Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, Hitchin JR, Stockley M, MacDonald E, Quesada MJ, Trivier E, Skeete J, Ovaa H, Moolenaar WH, Ryder H.
Bioorg Med Chem Lett (2016) 26 : 5403 -5410
PubMed 27780639 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.42	7.42

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3917975	CAMBRITAXESTAT	2.0	1	7.42

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3917975	CAMBRITAXESTAT	IC50	=	38.0	nM	7.42