Assay Detail
Functional
CHEMBL3865294
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold-Hopping of Aurones: 2-Arylideneimidazo[1,2-a]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.69 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3910987 | — | — | 1 | 7.19 |
| CHEMBL3973005 | — | — | 1 | 7.12 |
| CHEMBL2177353 | — | — | 1 | 6.22 |
| CHEMBL611941 | 4'-METHOXY-AURONE | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3910987 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3973005 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2177353 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL611941 | 4'-METHOXY-AURONE | IC50 | = | 600.0 | nM | 6.22 |