Assay Detail
Binding
CHEMBL3865403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin L
12
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.13 | 7.96 |
| K | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3907022 | — | — | 1 | 7.96 |
| CHEMBL3974129 | — | — | 1 | 7.71 |
| CHEMBL3930083 | — | — | 1 | 7.57 |
| CHEMBL3934979 | — | — | 1 | 7.52 |
| CHEMBL3921142 | — | — | 1 | 7.34 |
| CHEMBL3893138 | — | — | 1 | 7.31 |
| CHEMBL91704 | K-777 | 2.0 | 2 | 7.10 |
| CHEMBL3903171 | — | — | 1 | 6.96 |
| CHEMBL3982135 | — | — | 1 | 6.70 |
| CHEMBL3912190 | — | — | 1 | 6.55 |
| CHEMBL3902105 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3907022 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3974129 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL3930083 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3934979 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3921142 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3893138 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL91704 | K-777 | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL3903171 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3982135 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3912190 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL3902105 | — | Ki | = | 2020.0 | nM | 5.70 |
| CHEMBL91704 | K-777 | K | = | 9.2 | 10'5/M/s | - |