Assay Detail
Functional
CHEMBL3865668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CysLT release from IgE/human IL3 activated basophils in human whole blood preincubated for 30 mins followed by IL-3 stimulation for 15 mins and subsequent stimulation by IgE for 20 mins by LTC4-alkaline phosphatase coupled assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.09 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3415583 | — | — | 1 | 7.24 |
| CHEMBL3415610 | — | — | 1 | 7.21 |
| CHEMBL3943181 | — | — | 1 | 7.03 |
| CHEMBL3414584 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3415583 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3415610 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3943181 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3414584 | — | IC50 | = | 130.0 | nM | 6.89 |