Assay Detail
Functional
CHEMBL3865722
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.89 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3968287 | — | — | 1 | 6.28 |
| CHEMBL3971530 | — | — | 1 | 6.19 |
| CHEMBL3918448 | — | — | 1 | 5.56 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 3 | 5.52 |
| CHEMBL3932954 | — | — | 1 | 5.47 |
| CHEMBL3957283 | — | — | 1 | 5.28 |
| CHEMBL3929718 | — | — | 1 | 5.11 |
| CHEMBL3947532 | — | — | 1 | 5.08 |
| CHEMBL3941935 | — | — | 1 | 4.88 |
| CHEMBL3923284 | — | — | 1 | 4.76 |
| CHEMBL3914993 | — | — | 1 | 4.68 |
| CHEMBL1962393 | — | — | 1 | 4.65 |
| CHEMBL1962958 | — | — | 1 | 4.64 |
| CHEMBL1962390 | — | — | 1 | 4.57 |
| CHEMBL3953983 | — | — | 1 | 4.53 |
| CHEMBL3951720 | — | — | 1 | 4.49 |
| CHEMBL3896082 | — | — | 1 | 4.43 |
| CHEMBL3976810 | — | — | 1 | 4.37 |
| CHEMBL3962727 | — | — | 1 | 4.37 |
| CHEMBL3982656 | — | — | 1 | 4.31 |
| CHEMBL3938727 | — | — | 1 | 4.11 |
| CHEMBL3936613 | — | — | 1 | 4.09 |
| CHEMBL3956228 | — | — | 1 | 4.08 |
| CHEMBL3896701 | — | — | 1 | - |
| CHEMBL3959611 | — | — | 1 | - |
| CHEMBL3922590 | — | — | 1 | - |
| CHEMBL3967332 | — | — | 1 | - |
| CHEMBL3984881 | — | — | 1 | - |
| CHEMBL3941573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3968287 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3971530 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3918448 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL3932954 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL3957283 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL3929718 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL3947532 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3941935 | — | IC50 | = | 13120.0 | nM | 4.88 |
| CHEMBL3923284 | — | IC50 | = | 17310.0 | nM | 4.76 |
| CHEMBL3914993 | — | IC50 | = | 21010.0 | nM | 4.68 |
| CHEMBL1962393 | — | IC50 | = | 22160.0 | nM | 4.65 |
| CHEMBL1962958 | — | IC50 | = | 23120.0 | nM | 4.64 |
| CHEMBL1962390 | — | IC50 | = | 26780.0 | nM | 4.57 |
| CHEMBL3953983 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL3951720 | — | IC50 | = | 32330.0 | nM | 4.49 |
| CHEMBL3896082 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL3976810 | — | IC50 | = | 42360.0 | nM | 4.37 |
| CHEMBL3962727 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL3982656 | — | IC50 | = | 48910.0 | nM | 4.31 |
| CHEMBL3938727 | — | IC50 | = | 77100.0 | nM | 4.11 |
| CHEMBL3936613 | — | IC50 | = | 80300.0 | nM | 4.09 |
| CHEMBL3956228 | — | IC50 | = | 83130.0 | nM | 4.08 |
| CHEMBL3941573 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3922590 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3959611 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3896701 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3984881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3967332 | — | IC50 | > | 100000.0 | nM | - |