Assay Detail
Functional
CHEMBL3865944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells overexpressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.84 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL3955548 | — | — | 1 | 6.62 |
| CHEMBL3939072 | — | — | 1 | 6.42 |
| CHEMBL3927935 | — | — | 1 | 6.41 |
| CHEMBL3936933 | — | — | 1 | 6.29 |
| CHEMBL3983169 | — | — | 1 | 5.85 |
| CHEMBL3976115 | — | — | 1 | 5.78 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.78 |
| CHEMBL3895357 | — | — | 1 | 5.77 |
| CHEMBL509219 | — | — | 1 | 5.76 |
| CHEMBL3904272 | — | — | 1 | 5.73 |
| CHEMBL3914323 | — | — | 1 | 5.72 |
| CHEMBL3945818 | — | — | 1 | 5.68 |
| CHEMBL2441133 | — | — | 1 | 5.67 |
| CHEMBL2022334 | — | — | 1 | 5.67 |
| CHEMBL3954520 | — | — | 1 | 5.65 |
| CHEMBL3975187 | — | — | 1 | 5.64 |
| CHEMBL3966682 | — | — | 1 | 5.61 |
| CHEMBL3980099 | — | — | 1 | 5.58 |
| CHEMBL3932274 | — | — | 1 | 5.53 |
| CHEMBL3905337 | — | — | 1 | 5.41 |
| CHEMBL517968 | — | — | 1 | 5.39 |
| CHEMBL3984146 | — | — | 1 | 5.29 |
| CHEMBL3934506 | — | — | 1 | 5.11 |
| CHEMBL3962001 | — | — | 1 | - |
| CHEMBL3958444 | — | — | 1 | - |
| CHEMBL3926735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3955548 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3939072 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3927935 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3936933 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3983169 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3976115 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3895357 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL509219 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3904272 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL3914323 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3945818 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL2441133 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL2022334 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL3954520 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL3975187 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL3966682 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3980099 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3932274 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3905337 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL517968 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL3984146 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL3934506 | — | IC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL3962001 | — | IC50 | > | 8670.0 | nM | - |
| CHEMBL3958444 | — | IC50 | > | 12680.0 | nM | - |
| CHEMBL3926735 | — | IC50 | > | 13990.0 | nM | - |