Assay Detail
Binding
CHEMBL3865969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of NQO1 in human A549 cells assessed as decrease in cell survival incubated for 2 hrs measured after 7 days by Hoechst 33258 staining based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.77 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3939072 | — | — | 1 | 6.19 |
| CHEMBL3966682 | — | — | 1 | 5.92 |
| CHEMBL584338 | — | — | 1 | 5.89 |
| CHEMBL516585 | — | — | 1 | 5.75 |
| CHEMBL1098543 | — | — | 1 | 5.62 |
| CHEMBL238792 | — | — | 1 | 5.58 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3939072 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3966682 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL584338 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL516585 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1098543 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL238792 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 3400.0 | nM | 5.47 |