Assay Detail
Binding
CHEMBL3866152
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Inhibition of cresolase activity of mushroom tyrosinase using 4-[(4-Methylphenyl) azo]-phenol as substrate measured after 15 mins by spectrophotometric method
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Non-specific binding sites help to explain mixed inhibition in mushroom tyrosinase activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.65 | 5.30 |
| IC50 | 2 | 5.54 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27246 | CINNAMIC ACID | — | 2 | 5.54 |
| CHEMBL1045 | PHTHALIC ACID | — | 2 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL27246 | CINNAMIC ACID | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1045 | PHTHALIC ACID | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL1045 | PHTHALIC ACID | IC50 | = | 271790.0 | nM | - |