Assay Detail
Binding
CHEMBL3866569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1 inhibitor GF120918 and ABCC1 inhibitor MK-571 by flow cytometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-II |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL5748) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.00 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3974624 | — | — | 1 | 5.39 |
| CHEMBL3921707 | — | — | 1 | 5.35 |
| CHEMBL3263914 | — | — | 1 | 5.35 |
| CHEMBL3263916 | — | — | 1 | 5.32 |
| CHEMBL3263915 | — | — | 1 | 5.20 |
| CHEMBL3964042 | — | — | 1 | 5.14 |
| CHEMBL3945493 | — | — | 1 | 5.09 |
| CHEMBL3263569 | — | — | 1 | 5.05 |
| CHEMBL3263906 | — | — | 1 | 4.98 |
| CHEMBL3263904 | — | — | 1 | 4.97 |
| CHEMBL3263570 | — | — | 1 | 4.96 |
| CHEMBL3263913 | — | — | 1 | 4.94 |
| CHEMBL3263907 | — | — | 1 | 4.91 |
| CHEMBL3259861 | — | — | 1 | 4.86 |
| CHEMBL3263910 | — | — | 1 | 4.84 |
| CHEMBL3948408 | — | — | 1 | 4.81 |
| CHEMBL3928271 | — | — | 1 | 4.80 |
| CHEMBL3263909 | — | — | 1 | 4.76 |
| CHEMBL3914655 | — | — | 1 | 4.75 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3974624 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3921707 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3263914 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3263916 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3263915 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3964042 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3945493 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3263569 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3263906 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3263904 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3263570 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3263913 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3263907 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3259861 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3263910 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL3948408 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3928271 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3263909 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL3914655 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 25600.0 | nM | 4.59 |