Assay Detail
Functional
CHEMBL3866628
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Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.05 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604316 | — | — | 1 | 5.72 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.21 |
| CHEMBL1977780 | — | — | 1 | 5.14 |
| CHEMBL303846 | XANTHYLETIN | — | 1 | 5.10 |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | 5.04 |
| CHEMBL3900419 | — | — | 1 | 5.04 |
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | 5.02 |
| CHEMBL452242 | GLUTINOL | — | 1 | 4.89 |
| CHEMBL230558 | CUDRAFLAVONE A | — | 1 | 4.81 |
| CHEMBL14193 | 4-HYDROXYBENZALDEHYDE | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604316 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL140 | CURCUMIN | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1977780 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL303846 | XANTHYLETIN | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL448060 | ISOIMPERATORIN | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3900419 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL8659 | OLEIC ACID | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL452242 | GLUTINOL | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL230558 | CUDRAFLAVONE A | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL14193 | 4-HYDROXYBENZALDEHYDE | EC50 | = | 30200.0 | nM | 4.52 |