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Assay Detail

CHEMBL3867362

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Binding
Antagonist activity at progesterone receptor in human T47D cells incubated for 24 hrs in presence of P4 by alkaline phosphatase assay
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type T47D
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Progesterone receptor (CHEMBL208) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists.
Yamada A, Kazui Y, Yoshioka H, Tanatani A, Mori S, Kagechika H, Fujii S.
ACS Med Chem Lett (2016) 7 : 1028 -1033
PubMed 27994732 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 6.13 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3927163 — — 1 7.48
CHEMBL3917144 — — 1 6.96
CHEMBL3936121 — — 1 6.85
CHEMBL3912293 — — 1 6.77
CHEMBL3893240 — — 1 6.72
CHEMBL3945051 — — 1 6.66
CHEMBL3902219 — — 1 6.60
CHEMBL3911233 — — 1 6.57
CHEMBL3908173 — — 1 6.52
CHEMBL3953780 — — 1 6.50
CHEMBL3942784 — — 1 6.48
CHEMBL3930183 — — 1 6.43
CHEMBL3980435 — — 1 6.41
CHEMBL3895538 — — 1 6.39
CHEMBL3952612 — — 1 6.35
CHEMBL3971739 — — 1 6.33
CHEMBL3986969 — — 1 6.31
CHEMBL3929091 — — 1 6.30
CHEMBL3915906 — — 1 6.29
CHEMBL3898358 — — 1 6.28
CHEMBL3903419 — — 1 6.19
CHEMBL3966839 — — 1 6.19
CHEMBL3939189 — — 1 6.17
CHEMBL3982227 — — 1 6.13
CHEMBL3961285 — — 1 6.09
CHEMBL3924894 — — 1 6.09
CHEMBL3912431 — — 1 6.02
CHEMBL3930349 — — 1 6.00
CHEMBL3943861 — — 1 5.89
CHEMBL3972388 — — 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3927163 — IC50 = 33.0 nM 7.48
CHEMBL3917144 — IC50 = 110.0 nM 6.96
CHEMBL3936121 — IC50 = 140.0 nM 6.85
CHEMBL3912293 — IC50 = 170.0 nM 6.77
CHEMBL3893240 — IC50 = 190.0 nM 6.72
CHEMBL3945051 — IC50 = 220.0 nM 6.66
CHEMBL3902219 — IC50 = 250.0 nM 6.60
CHEMBL3911233 — IC50 = 270.0 nM 6.57
CHEMBL3908173 — IC50 = 300.0 nM 6.52
CHEMBL3953780 — IC50 = 320.0 nM 6.50
CHEMBL3942784 — IC50 = 330.0 nM 6.48
CHEMBL3930183 — IC50 = 370.0 nM 6.43
CHEMBL3980435 — IC50 = 390.0 nM 6.41
CHEMBL3895538 — IC50 = 410.0 nM 6.39
CHEMBL3952612 — IC50 = 450.0 nM 6.35
CHEMBL3971739 — IC50 = 470.0 nM 6.33
CHEMBL3986969 — IC50 = 490.0 nM 6.31
CHEMBL3929091 — IC50 = 500.0 nM 6.30
CHEMBL3915906 — IC50 = 510.0 nM 6.29
CHEMBL3898358 — IC50 = 520.0 nM 6.28
CHEMBL3903419 — IC50 = 650.0 nM 6.19
CHEMBL3966839 — IC50 = 640.0 nM 6.19
CHEMBL3939189 — IC50 = 670.0 nM 6.17
CHEMBL3982227 — IC50 = 740.0 nM 6.13
CHEMBL3961285 — IC50 = 810.0 nM 6.09
CHEMBL3924894 — IC50 = 820.0 nM 6.09
CHEMBL3912431 — IC50 = 960.0 nM 6.02
CHEMBL3930349 — IC50 = 990.0 nM 6.00
CHEMBL3943861 — IC50 = 1300.0 nM 5.89
CHEMBL3972388 — IC50 = 1300.0 nM 5.89
CHEMBL3956621 — IC50 = 1500.0 nM 5.82
CHEMBL3926140 — IC50 = 1600.0 nM 5.80
CHEMBL3942112 — IC50 = 1600.0 nM 5.80
CHEMBL3921236 — IC50 = 1700.0 nM 5.77
CHEMBL3970606 — IC50 = 2000.0 nM 5.70
CHEMBL3931396 — IC50 = 2200.0 nM 5.66
CHEMBL3951528 — IC50 = 2200.0 nM 5.66
CHEMBL3983391 — IC50 = 2200.0 nM 5.66
CHEMBL3949203 — IC50 = 2600.0 nM 5.58
CHEMBL2441096 — IC50 = 2800.0 nM 5.55
CHEMBL3940435 — IC50 = 3000.0 nM 5.52
CHEMBL3957844 — IC50 = 3500.0 nM 5.46
CHEMBL3917444 — IC50 = 3800.0 nM 5.42
CHEMBL2441094 — IC50 = 5000.0 nM 5.30
CHEMBL3911549 — IC50 = 6000.0 nM 5.22