Assay Detail
Functional
CHEMBL3867578
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Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.91 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3982147 | — | — | 1 | 6.96 |
| CHEMBL3912218 | — | — | 1 | 6.92 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.34 |
| CHEMBL3939105 | — | — | 1 | 6.30 |
| CHEMBL3930106 | — | — | 1 | 6.19 |
| CHEMBL3949423 | — | — | 1 | 6.11 |
| CHEMBL3929190 | — | — | 1 | 6.10 |
| CHEMBL3913881 | — | — | 1 | 5.96 |
| CHEMBL3971500 | — | — | 1 | 5.96 |
| CHEMBL3976137 | — | — | 1 | 5.95 |
| CHEMBL3969307 | — | — | 1 | 5.90 |
| CHEMBL3941885 | — | — | 1 | 5.87 |
| CHEMBL560339 | — | — | 1 | 5.83 |
| CHEMBL3902126 | — | — | 1 | 5.78 |
| CHEMBL3911611 | — | — | 1 | 5.73 |
| CHEMBL3930475 | — | — | 1 | 5.51 |
| CHEMBL3977574 | — | — | 1 | 4.96 |
| CHEMBL3940614 | — | — | 1 | 4.94 |
| CHEMBL3986773 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3982147 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3912218 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3939105 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3930106 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3949423 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3929190 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3913881 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3971500 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3976137 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3969307 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3941885 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL560339 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3902126 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3911611 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3930475 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL3977574 | — | IC50 | = | 10840.0 | nM | 4.96 |
| CHEMBL3940614 | — | IC50 | = | 11390.0 | nM | 4.94 |
| CHEMBL3986773 | — | IC50 | = | 11630.0 | nM | 4.93 |