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Assay Detail

CHEMBL3867734

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Functional
Cytotoxicity against human NCI-H292 cells assessed as decrease in cell viability after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H292
Confidence 1 — Organism
Curated By Autocuration

Publication

Chemistry of Renieramycins. 15. Synthesis of 22-O-Ester Derivatives of Jorunnamycin A and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cells.
Sirimangkalakitti N, Chamni S, Charupant K, Chanvorachote P, Mori N, Saito N, Suwanborirux K.
J Nat Prod (2016) 79 : 2089 -2093
PubMed 27487087 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.62 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3964130 1 8.96
CHEMBL3960155 1 8.43
CHEMBL3985581 1 8.31
CHEMBL3943006 1 8.19
CHEMBL3952987 1 7.96
CHEMBL3953689 1 7.75
CHEMBL3961689 1 7.72
CHEMBL3899308 1 7.70
CHEMBL3925303 1 7.68
CHEMBL3890495 1 7.66
CHEMBL451147 RENIERAMYCIN M 1 7.64
CHEMBL3908215 1 7.60
CHEMBL3980756 1 7.52
CHEMBL3934199 1 7.36
CHEMBL3892157 1 7.31
CHEMBL3927381 1 7.29
CHEMBL3926052 1 7.25
CHEMBL3964268 1 7.22
CHEMBL3984007 1 6.66
CHEMBL3962442 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3964130 IC50 = 1.1 nM 8.96
CHEMBL3960155 IC50 = 3.7 nM 8.43
CHEMBL3985581 IC50 = 4.9 nM 8.31
CHEMBL3943006 IC50 = 6.4 nM 8.19
CHEMBL3952987 IC50 = 11.0 nM 7.96
CHEMBL3953689 IC50 = 18.0 nM 7.75
CHEMBL3961689 IC50 = 19.0 nM 7.72
CHEMBL3899308 IC50 = 20.0 nM 7.70
CHEMBL3925303 IC50 = 21.0 nM 7.68
CHEMBL3890495 IC50 = 22.0 nM 7.66
CHEMBL451147 RENIERAMYCIN M IC50 = 23.0 nM 7.64
CHEMBL3908215 IC50 = 25.0 nM 7.60
CHEMBL3980756 IC50 = 30.0 nM 7.52
CHEMBL3934199 IC50 = 44.0 nM 7.36
CHEMBL3892157 IC50 = 49.0 nM 7.31
CHEMBL3927381 IC50 = 51.0 nM 7.29
CHEMBL3926052 IC50 = 56.0 nM 7.25
CHEMBL3964268 IC50 = 60.0 nM 7.22
CHEMBL3984007 IC50 = 220.0 nM 6.66
CHEMBL3962442 IC50 = 570.0 nM 6.24