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Assay Detail

CHEMBL3867975

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Publication

Cytotoxic and Antibacterial Preussomerins from the Mangrove Endophytic Fungus Lasiodiplodia theobromae ZJ-HQ1.
Chen S, Chen D, Cai R, Cui H, Long Y, Lu Y, Li C, She Z.
J Nat Prod (2016) 79 : 2397 -2402
PubMed 27560695 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.94 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL417 EPIRUBICIN 4.0 1 6.38
CHEMBL3963585 1 4.85
CHEMBL3893130 1 4.82
CHEMBL3934297 1 4.75
CHEMBL3912343 1 4.72
CHEMBL3894364 1 4.72
CHEMBL487725 PREUSSOMERIN D 1 4.68
CHEMBL3892151 1 4.57
CHEMBL3956586 1 -
CHEMBL485874 1 -
CHEMBL487724 PREUSSOMERIN C 1 -
CHEMBL3965533 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL417 EPIRUBICIN IC50 = 420.0 nM 6.38
CHEMBL3963585 IC50 = 14000.0 nM 4.85
CHEMBL3893130 IC50 = 15000.0 nM 4.82
CHEMBL3934297 IC50 = 18000.0 nM 4.75
CHEMBL3912343 IC50 = 19000.0 nM 4.72
CHEMBL3894364 IC50 = 19000.0 nM 4.72
CHEMBL487725 PREUSSOMERIN D IC50 = 21000.0 nM 4.68
CHEMBL3892151 IC50 = 27000.0 nM 4.57
CHEMBL3956586 IC50 > 100000.0 nM -
CHEMBL485874 IC50 > 100000.0 nM -
CHEMBL487724 PREUSSOMERIN C IC50 > 100000.0 nM -
CHEMBL3965533 IC50 > 100000.0 nM -