Assay Detail
Binding
CHEMBL3868072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubated for 60 mins followed by substrate addition measured after 4 hrs by Topcount method
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AD293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.76 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3913908 | — | — | 1 | 9.14 |
| CHEMBL3922888 | — | — | 1 | 8.43 |
| CHEMBL3980889 | — | — | 1 | 8.15 |
| CHEMBL3968178 | — | — | 1 | 8.10 |
| CHEMBL3952032 | — | — | 1 | 8.05 |
| CHEMBL3960724 | — | — | 1 | 8.05 |
| CHEMBL3931836 | — | — | 1 | 7.96 |
| CHEMBL3894912 | — | — | 1 | 7.92 |
| CHEMBL3983734 | — | — | 1 | 7.82 |
| CHEMBL3891718 | — | — | 1 | 7.82 |
| CHEMBL3964421 | — | — | 1 | 7.72 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 7.32 |
| CHEMBL3938615 | — | — | 1 | 7.17 |
| CHEMBL75 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3913908 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL3922888 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3980889 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3968178 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3952032 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3960724 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3931836 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3894912 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3983734 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3891718 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3964421 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3938615 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL75 | — | IC50 | = | 1800.0 | nM | 5.75 |