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Assay Detail

CHEMBL3868094

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial against of Leishmania donovani LV9 axenic amastigotes after 72 hrs by SYBR1 green-based qPCR analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Jagu E, Pomel S, Diez-Martinez A, Ramiandrasoa F, Krauth-Siegel RL, Pethe S, Blonski C, Labruère R, Loiseau PM.
Bioorg Med Chem (2017) 25 : 84 -90
PubMed 27793448 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.92 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL125 MILTEFOSINE 4.0 1 5.72
CHEMBL19612 SPERMIDINE 3.0 1 5.08
CHEMBL3935427 1 4.96
CHEMBL3929012 1 4.94
CHEMBL3982145 1 4.57
CHEMBL3911154 1 4.22
CHEMBL3974072 1 -
CHEMBL3973073 1 -
CHEMBL3963859 1 -
CHEMBL3920101 1 -
CHEMBL3892084 1 -
CHEMBL3981165 1 -
CHEMBL3938030 1 -
CHEMBL3899791 1 -
CHEMBL3901047 1 -
CHEMBL55 PENTAMIDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL125 MILTEFOSINE IC50 = 1900.0 nM 5.72
CHEMBL19612 SPERMIDINE IC50 = 8300.0 nM 5.08
CHEMBL3935427 IC50 = 10900.0 nM 4.96
CHEMBL3929012 IC50 = 11500.0 nM 4.94
CHEMBL3982145 IC50 = 27000.0 nM 4.57
CHEMBL3911154 IC50 = 60500.0 nM 4.22
CHEMBL3974072 IC50 > 100000.0 nM -
CHEMBL3973073 IC50 > 100000.0 nM -
CHEMBL3963859 IC50 > 100000.0 nM -
CHEMBL3920101 IC50 > 100000.0 nM -
CHEMBL3892084 IC50 > 100000.0 nM -
CHEMBL3981165 IC50 > 100000.0 nM -
CHEMBL3938030 IC50 > 100000.0 nM -
CHEMBL3899791 IC50 > 100000.0 nM -
CHEMBL3901047 IC50 > 100000.0 nM -
CHEMBL55 PENTAMIDINE IC50 - -