Assay Detail
Functional
CHEMBL3868166
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Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced TNFalpha release preincubated for 45 mins followed by LPS addition after 18 hrs by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.47 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3915997 | — | — | 1 | 7.85 |
| CHEMBL3964502 | — | — | 1 | 7.80 |
| CHEMBL3977631 | — | — | 1 | 7.54 |
| CHEMBL3937635 | — | — | 1 | 7.38 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3915997 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3964502 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3977631 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3937635 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL131 | PREDNISOLONE | IC50 | = | 160.0 | nM | 6.80 |