Assay Detail
Functional
CHEMBL3868181
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Antiinflammatory activity in rat whole blood assessed as inhibition of LPS-induced TNFalpha release preincubated for 45 mins followed by LPS addition after 18 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.91 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3915997 | — | — | 1 | 8.48 |
| CHEMBL3937635 | — | — | 1 | 8.12 |
| CHEMBL3964502 | — | — | 1 | 7.75 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3915997 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3937635 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3964502 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 50.0 | nM | 7.30 |