Assay Detail
Binding
CHEMBL3868295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K-beta (unknown origin) by KinaseGlo assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.86 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3969716 | — | — | 1 | 6.52 |
| CHEMBL3960012 | — | — | 1 | 6.44 |
| CHEMBL3905342 | — | — | 1 | 6.18 |
| CHEMBL3896413 | — | — | 1 | 6.17 |
| CHEMBL3966263 | — | — | 1 | 6.07 |
| CHEMBL3930000 | — | — | 1 | 6.02 |
| CHEMBL3977135 | — | — | 1 | 5.99 |
| CHEMBL3921081 | — | — | 1 | 5.83 |
| CHEMBL3977066 | — | — | 1 | 5.78 |
| CHEMBL3914282 | — | — | 1 | 5.75 |
| CHEMBL3944013 | — | — | 1 | 5.71 |
| CHEMBL3948901 | — | — | 1 | 5.71 |
| CHEMBL3910692 | — | — | 1 | 5.41 |
| CHEMBL3947814 | — | — | 1 | 5.32 |
| CHEMBL3933360 | — | — | 1 | 5.04 |
| CHEMBL3939028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3969716 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL3960012 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3905342 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL3896413 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL3966263 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3930000 | — | IC50 | = | 956.0 | nM | 6.02 |
| CHEMBL3977135 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3921081 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL3977066 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3914282 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3944013 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL3948901 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL3910692 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL3947814 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL3933360 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL3939028 | — | IC50 | > | 9100.0 | nM | - |