Assay Detail
Functional
CHEMBL3868432
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Agonist activity at rat GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4-AM dye based FLIPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.87 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3923877 | — | — | 1 | 9.40 |
| CHEMBL3927863 | — | — | 1 | 8.00 |
| CHEMBL3954105 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3923877 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3927863 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3954105 | — | EC50 | = | 630.0 | nM | 6.20 |