Assay Detail
Functional
CHEMBL3868665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity against okadaic acid-induced tau phosphorylation-mediated cell death in human SH-SY5Y cells assessed as increase in cell viability after 24 hrs by XTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.16 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3958859 | — | — | 1 | 6.82 |
| CHEMBL3907011 | — | — | 1 | 6.66 |
| CHEMBL3945723 | — | — | 1 | 6.29 |
| CHEMBL3920392 | — | — | 1 | 6.27 |
| CHEMBL3922437 | — | — | 1 | 5.92 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.71 |
| CHEMBL238756 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3958859 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3907011 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3945723 | — | EC50 | = | 516.0 | nM | 6.29 |
| CHEMBL3920392 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3922437 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL659 | GALANTAMINE | EC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL238756 | — | EC50 | = | 3350.0 | nM | 5.47 |