Assay Detail
Functional
CHEMBL3869939
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Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 after 70 hrs by Alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.13 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3949602 | — | — | 1 | 7.82 |
| CHEMBL48217 | DAPI | — | 1 | 7.75 |
| CHEMBL3940835 | — | — | 1 | 7.72 |
| CHEMBL563834 | — | — | 1 | 7.51 |
| CHEMBL3958245 | — | — | 1 | 7.51 |
| CHEMBL3970372 | — | — | 1 | 7.32 |
| CHEMBL3986957 | — | — | 1 | 7.19 |
| CHEMBL3931507 | — | — | 1 | 7.17 |
| CHEMBL3917404 | — | — | 1 | 6.28 |
| CHEMBL3938393 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3949602 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL48217 | DAPI | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3940835 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL563834 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3958245 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3970372 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3986957 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3931507 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3917404 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL3938393 | — | IC50 | = | 8433.0 | nM | 5.07 |