Assay Detail
Binding
CHEMBL3870595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CETP (unknown origin) assessed as inhibition of BODIPY-labeled cholesteryl transfer to fluorescent substrate by fluorimetric assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkene scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.31 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800807 | ANACETRAPIB | 3.0 | 1 | 7.40 |
| CHEMBL3955613 | — | — | 1 | 7.22 |
| CHEMBL3946904 | — | — | 1 | 7.16 |
| CHEMBL3913485 | — | — | 1 | 7.16 |
| CHEMBL3976202 | — | — | 1 | 7.10 |
| CHEMBL3931395 | — | — | 1 | 6.77 |
| CHEMBL3909889 | — | — | 1 | 6.72 |
| CHEMBL3964613 | — | — | 1 | 6.66 |
| CHEMBL3958109 | — | — | 1 | 6.52 |
| CHEMBL3922480 | — | — | 1 | 6.46 |
| CHEMBL3918826 | — | — | 1 | 6.44 |
| CHEMBL3904480 | — | — | 1 | 6.43 |
| CHEMBL3963665 | — | — | 1 | 6.38 |
| CHEMBL3907440 | — | — | 1 | 6.28 |
| CHEMBL3941452 | — | — | 1 | 6.07 |
| CHEMBL3890759 | — | — | 1 | 6.04 |
| CHEMBL3903893 | — | — | 1 | 6.03 |
| CHEMBL3984241 | — | — | 1 | 5.79 |
| CHEMBL3958905 | — | — | 1 | 5.68 |
| CHEMBL3960862 | — | — | 1 | 5.56 |
| CHEMBL3927748 | — | — | 1 | 5.45 |
| CHEMBL3975244 | — | — | 1 | 5.18 |
| CHEMBL3966113 | — | — | 1 | 4.68 |
| CHEMBL3962127 | — | — | 1 | - |
| CHEMBL3901482 | — | — | 1 | - |
| CHEMBL3963680 | — | — | 1 | - |
| CHEMBL3984332 | — | — | 1 | - |
| CHEMBL3972579 | — | — | 1 | - |
| CHEMBL3965575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800807 | ANACETRAPIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3955613 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3946904 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3913485 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3976202 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3931395 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3909889 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3964613 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3958109 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3922480 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3918826 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3904480 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3963665 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3907440 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3941452 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3890759 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3903893 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3984241 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL3958905 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3960862 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3927748 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL3975244 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL3966113 | — | IC50 | = | 20970.0 | nM | 4.68 |
| CHEMBL3962127 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3901482 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3963680 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3984332 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3972579 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3965575 | — | IC50 | > | 50000.0 | nM | - |