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Assay Detail

CHEMBL3870698

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifilarial activity against Brugia malayi microfilariae isolated from peritoneal cavity of infected Meriones unguiculatus assessed as loss of motility incubated for 48 hrs by microscopy
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Brugia malayi
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Publication

Sulfonamide chalcones: Synthesis and in vitro exploration for therapeutic potential against Brugia malayi.
Bahekar SP, Hande SV, Agrawal NR, Chandak HS, Bhoj PS, Goswami K, Reddy MVR.
Eur J Med Chem (2016) 124 : 262 -269
PubMed 27592395 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.74 5.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3954611 1 5.36
CHEMBL3952676 1 5.35
CHEMBL3409829 1 5.34
CHEMBL3409826 1 5.09
CHEMBL1169729 1 5.01
CHEMBL3903350 1 4.82
CHEMBL3892384 1 4.77
CHEMBL3891450 1 4.70
CHEMBL3928031 1 4.50
CHEMBL3890218 1 4.24
CHEMBL3898731 1 4.22
CHEMBL3950306 1 4.16
CHEMBL371723 1 4.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3954611 IC50 = 4400.0 nM 5.36
CHEMBL3952676 IC50 = 4500.0 nM 5.35
CHEMBL3409829 IC50 = 4600.0 nM 5.34
CHEMBL3409826 IC50 = 8200.0 nM 5.09
CHEMBL1169729 IC50 = 9700.0 nM 5.01
CHEMBL3903350 IC50 = 15000.0 nM 4.82
CHEMBL3892384 IC50 = 17000.0 nM 4.77
CHEMBL3891450 IC50 = 20000.0 nM 4.70
CHEMBL3928031 IC50 = 32000.0 nM 4.50
CHEMBL3890218 IC50 = 58000.0 nM 4.24
CHEMBL3898731 IC50 = 60000.0 nM 4.22
CHEMBL3950306 IC50 = 70000.0 nM 4.16
CHEMBL371723 IC50 = 82000.0 nM 4.09