Assay Detail
Functional
CHEMBL3870934
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Cytotoxicity against human SK-MEL-2 cells assessed as reduction in cell proliferation measured after 48 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.35 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 9.00 |
| CHEMBL3901355 | — | — | 1 | 5.84 |
| CHEMBL3964231 | — | — | 1 | 5.74 |
| CHEMBL1962571 | — | — | 1 | 5.26 |
| CHEMBL391411 | — | — | 1 | 5.05 |
| CHEMBL1962593 | — | — | 1 | 5.03 |
| CHEMBL1962592 | — | — | 1 | 5.01 |
| CHEMBL3944420 | — | — | 1 | 4.88 |
| CHEMBL1962464 | — | — | 1 | 4.84 |
| CHEMBL1962702 | — | — | 1 | 4.82 |
| CHEMBL3916483 | — | — | 1 | 4.71 |
| CHEMBL3935469 | — | — | 1 | 4.71 |
| CHEMBL3958166 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3901355 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3964231 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL1962571 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL391411 | — | IC50 | = | 8860.0 | nM | 5.05 |
| CHEMBL1962593 | — | IC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL1962592 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL3944420 | — | IC50 | = | 13050.0 | nM | 4.88 |
| CHEMBL1962464 | — | IC50 | = | 14280.0 | nM | 4.84 |
| CHEMBL1962702 | — | IC50 | = | 15170.0 | nM | 4.82 |
| CHEMBL3916483 | — | IC50 | = | 19330.0 | nM | 4.71 |
| CHEMBL3935469 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL3958166 | — | IC50 | = | 19610.0 | nM | 4.71 |