Assay Detail
Functional
CHEMBL3870935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT15 cells assessed as reduction in cell proliferation measured after 48 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.94 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.06 |
| CHEMBL3901355 | — | — | 1 | 6.05 |
| CHEMBL3964231 | — | — | 1 | 5.43 |
| CHEMBL1962571 | — | — | 1 | 5.07 |
| CHEMBL391411 | — | — | 1 | 5.00 |
| CHEMBL1962464 | — | — | 1 | 4.68 |
| CHEMBL1962592 | — | — | 1 | 4.67 |
| CHEMBL1962593 | — | — | 1 | 4.64 |
| CHEMBL3958166 | — | — | 1 | 4.59 |
| CHEMBL3944420 | — | — | 1 | 4.57 |
| CHEMBL1962702 | — | — | 1 | 4.55 |
| CHEMBL3935469 | — | — | 1 | 4.46 |
| CHEMBL3916483 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 872.0 | nM | 6.06 |
| CHEMBL3901355 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3964231 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL1962571 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL391411 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL1962464 | — | IC50 | = | 20850.0 | nM | 4.68 |
| CHEMBL1962592 | — | IC50 | = | 21310.0 | nM | 4.67 |
| CHEMBL1962593 | — | IC50 | = | 22670.0 | nM | 4.64 |
| CHEMBL3958166 | — | IC50 | = | 25740.0 | nM | 4.59 |
| CHEMBL3944420 | — | IC50 | = | 26910.0 | nM | 4.57 |
| CHEMBL1962702 | — | IC50 | = | 28060.0 | nM | 4.55 |
| CHEMBL3935469 | — | IC50 | = | 34590.0 | nM | 4.46 |
| CHEMBL3916483 | — | IC50 | = | 38390.0 | nM | 4.42 |