Assay Detail
Binding
CHEMBL3870938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N- terminal GST-tagged TrkA cytoplasmic domain (436 to 790 residues) expressed in baculovirus infected sf21 cells using biotinylated peptide substrate incubated for 15 mins followed by addition of ATP measured after 30 mins by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.79 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176544 | — | — | 1 | 8.52 |
| CHEMBL3901355 | — | — | 1 | 6.63 |
| CHEMBL3964231 | — | — | 1 | 6.42 |
| CHEMBL391411 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176544 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3901355 | — | IC50 | = | 231.5 | nM | 6.63 |
| CHEMBL3964231 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL391411 | — | IC50 | = | 2545.0 | nM | 5.59 |