Assay Detail
Functional
CHEMBL3871352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against intracellular amastigote stage of Leishmania donovani MHOM/ET/67/HU3 infected in human THP1 cells assessed as parasite growth measured after 72 hrs by luciferase reporter gene assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Arylthiosemicarbazones as antileishmanial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 5.51 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.05 |
| CHEMBL3893454 | — | — | 1 | 6.10 |
| CHEMBL3962732 | — | — | 1 | 5.92 |
| CHEMBL3921467 | — | — | 1 | 5.92 |
| CHEMBL3890031 | — | — | 1 | 5.90 |
| CHEMBL3927005 | — | — | 1 | 5.85 |
| CHEMBL3953394 | — | — | 1 | 5.72 |
| CHEMBL3974423 | — | — | 1 | 5.68 |
| CHEMBL3920368 | — | — | 1 | 5.66 |
| CHEMBL3924303 | — | — | 1 | 5.58 |
| CHEMBL3907823 | — | — | 1 | 5.39 |
| CHEMBL3973694 | — | — | 1 | 5.37 |
| CHEMBL3965932 | — | — | 1 | 5.30 |
| CHEMBL3957992 | — | — | 1 | 5.28 |
| CHEMBL3909127 | — | — | 1 | 5.27 |
| CHEMBL330453 | — | — | 1 | 5.19 |
| CHEMBL3896301 | — | — | 1 | 5.17 |
| CHEMBL3903479 | — | — | 1 | 5.14 |
| CHEMBL3971223 | — | — | 1 | 5.09 |
| CHEMBL3982413 | — | — | 1 | 5.05 |
| CHEMBL3909515 | — | — | 1 | 5.05 |
| CHEMBL3946974 | — | — | 1 | 5.05 |
| CHEMBL3936581 | — | — | 1 | 5.03 |
| CHEMBL3975509 | — | — | 1 | - |
| CHEMBL3898959 | — | — | 1 | - |
| CHEMBL3900074 | — | — | 1 | - |
| CHEMBL90867 | — | — | 1 | - |
| CHEMBL3960152 | — | — | 1 | - |
| CHEMBL3944217 | — | — | 1 | - |
| CHEMBL1818881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3893454 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3962732 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3921467 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3890031 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL3927005 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3953394 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3974423 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3920368 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3924303 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3907823 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3973694 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3965932 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3957992 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3909127 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL330453 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3896301 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3903479 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3971223 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3982413 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3909515 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3946974 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3936581 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3975509 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3898959 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3900074 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL90867 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3960152 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3944217 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1818881 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1818885 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL90808 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3899352 | — | EC50 | > | 10000.0 | nM | - |